You should see my old boss' desktop. Windows XP but there had to be over 300 icons on the desktop.

Dang - you couldn't find squat as there were just too many to try and find something - they all blend in and have similar colors etc.
Hot Keys, and a Launcher are some of the best ways to support multiple icons.

In general I have over 300 applications installed so it would drive me crazy to just let the applications dump on the desktop.
I put the main ones I use on either a Launcher or the Taskbar

I have a cool script you can run if you have Excel on your system.