I'm still scared to death about overwriting some tweak that I've made somewhere over the past 3 years. (Ouch)
Updating most always means you
could lose some/all of your custom 'tweaks'. IF you have a record of the tweaks you made; name, file(s) modified, etc., then after an upgrade you will have to add them back in. The easiest method is to use a program such as "Beyond Compare" or "Araxis Merge".
Also, be aware that the second phase of the upgrade (7.6) has been said to go into Beta in about 2 weeks. So, if everything goes as planned, this should be released in the next 30-60 days, hopefully.
Thus, there is a good possibility that some/all 'tweaks' will be lost again. But as Gizmo stated, the current update (7.5.7) has some critical security updates and the addition of the StopForumSpam feature. The choice is yours.