I too dislike users being able to edit the subject... I'd like to see an option to not allow users to change the topic in a reply, kind of like how the Quick Reply box works...

I'm pretty sure you can edit it out by:
Find in newreply.tpl:
Code
<input type="text" name="Subject" maxlength="{$config.SUBJECT_LENGTH}" class="form-input" size="60" tabindex="1" value="{$Subject}" />

Replace With:
Code
<input type="hidden" name="Subject" maxlength="{$config.SUBJECT_LENGTH}" class="form-input" size="60" tabindex="1" value="{$Subject}" />{$Subject}

This would use the subject of the parent they're responding to, and show the subject in the new reply as a non editable html entry.

Completely untested though...

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