Check out this thread:
http://www.scriptkeeper.com/ubb/Forum4/HTML/002460.html As well as read, write and execute permissions, some win2k setups need to have 'change' permissions set as well, else you'll experience severe slowdown.
If you haven't already, it is also worth switching to the ISAPI version of perl. If you need help with that, just ask.
Just a thought <img src="https://www.ubbcentral.com/boards/images/graemlins/smile.gif" alt="" />