the only table to worry about is ubbt_POSTS -- i have a site where that table is 1.6gig and runs fine..
i've always wanted to split the posts table up and syphon off the POST_BODY or DEFAULT_POST_BODY as its own parallel table.. that would divide table size by roughly half
MyISAM shouldn't be a prob..
Also, once you are 'up / running smooth' -- turn off the slow query dealio.. that should only be there as a temp. tool