Well if you want a REAL annoying experience then install Windows Vista 64 Bit and run it for a while. I've tried it a few times but the hoops and hassles you have to keep going through just are not worth it for me on a production system. I'll still use it for like a Graphics station but not a daily user box.

Heck, not even Flash installs on native 64 Bit

If you don't do much on the PC and you have all new hardware then you might get along okay with 64 Bit, but once you start to do a little bit more then the tweaks and workarounds start to flourish. Too bad really since 64 Bit has been around for probably at least a decade if not more.